doi: 10.1176/jnp.10.2.230a
In the present study, high level of PGC-1 induced the expression of genes involved in lipid metabolism and detoxification, but failed to promote the expression of Nrf2 regulated genes involved in glutathione synthesis
mephedrone, methedrone, and - pyrrolidinovalerophenone Dimetamfetamine (dimethylamphetamine) Ephedrine*** Epinephrine**** (adrenaline) Etamivan Ethylphenidate Etilamfetamine Etilefrine Famprofazone Fenbutrazate Fencamfamin Heptaminol Hydroxyamfetamine (parahydroxyamphetamine) Isometheptene Levmetamfetamine Meclofenoxate Methylenedioxymetham- phetamine Methylephedrine*** Methylnaphthidate [(()-methyl-2-(naphthalen-2-yl)-2-(piperidin-2-yl)acetate] Methylphenidate Midodrine Nikethamide Norfenefrine Octodrine (1,5-dimethylhex- ylamine) Octopamine Oxilofrine (methylsynephrine) Pemoline Pentetrazol Phenethylamine and its derivatives Phenmetrazine Phenpromethamine Propylhexedrine Pseudoephedrine***** Selegiline Sibutramine Solriamfetol Strychnine Tenamfetamine (methylenedioxyamphet- amine) Tesofensine Tuaminoheptane and other substances with a similar chemical structure or similar biological effect(s)
However, our study did not directly assess mitochondrial function or ROS levels, and thus, this mechanism remains speculative
The inclusion of Vitamin B12, a complex organometallic compound, provides a critical cofactor for enzymes like methionine synthase, directly linking it to the methionine cycle and folate metabolism, as well as fatty acid oxidation
